I was just reading on animenewsnetwork.com about supposed rumors about why there hasn’t been a Yotsuba anime series yet. You can read the entire thing over but what I wanted to comment on was Yotsuba’s creator, Kiyohiko Azuma, statement that a Yotsuba anime would be hard to do since it has “idiosyncratic storytelling”.
I can think of two different animation houses that have the ability to handle the anime adaptation. The first is Hal Film Maker. With Aria, Skectchbook and Somedays Dreamer’s Season 2 under their belts they’ve shown they can handle making the slow pacing of a slice-of-life show interesting. The other would be Brains Base. They’ve shown in Kamichu and Natsume’s Book of Friends that they can handle slice-of-life shows and infusing the characters with warmth so that you can’t help but love them. Either would make good picks.